Portillo's menu features a variety of Chicago-style foods, with their signature item being the Italian beef sandwich. This sandwich can be customized with sweet or hot peppers and dipped in gravy for added flavor. They also serve classic Chicago-style hot dogs, which come topped with mustard, relish, onions, tomatoes, pickles, sport peppers, and celery salt.

Burgers and Sausages:
In addition to hot dogs, Portillo's offers a selection of char-grilled burgers made from 100% beef. Their Maxwell Street Polish sausage is another popular option, grilled and topped with mustard and grilled onions for a bold, savory taste.

Pasta and Salads:
The menu includes hearty pasta dishes such as baked mostaccioli and spaghetti, which can be ordered with marinara or meat sauce. Fresh salads are also available, including options like the chopped salad and Caesar salad, often topped with chicken or bacon.